{"id":2854,"date":"2022-12-21T16:47:20","date_gmt":"2022-12-21T14:47:20","guid":{"rendered":"https:\/\/www.uutescientific.com\/?post_type=scientific-resources&p=2854"},"modified":"2023-08-02T10:06:15","modified_gmt":"2023-08-02T07:06:15","slug":"immuunijarjestelmamme-tarvitsee-mikrobialtistusta-re-connecting-nature-uutteen-tuoma-monimuotoinen-mikrobialtistus-tukee-immuunijarjestelman-toimintaa","status":"publish","type":"scientific-resources","link":"https:\/\/www.uutescientific.com\/fi\/scientific-resources\/immuunijarjestelmamme-tarvitsee-mikrobialtistusta-re-connecting-nature-uutteen-tuoma-monimuotoinen-mikrobialtistus-tukee-immuunijarjestelman-toimintaa\/","title":{"rendered":"Immuunij\u00e4rjestelm\u00e4mme tarvitsee mikrobialtistusta \u2013 Re-Connecting Nature\u2122<\/sup> -uutteen tuoma monimuotoinen mikrobialtistus tukee immuunij\u00e4rjestelm\u00e4n toimintaa"},"content":{"rendered":"[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_image=”459″ bg_position=”left top” background_image_loading=”default” bg_repeat=”no-repeat” scene_position=”center” top_padding=”5%” constrain_group_1=”yes” bottom_padding=”5%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_custom_heading text=”Immuunij\u00e4rjestelm\u00e4mme tarvitsee mikrobialtistusta \u2013 Re-Connecting Nature\u00ae<\/sup> -uutteen tuoma monimuotoinen mikrobialtistus tukee immuunij\u00e4rjestelm\u00e4n toimintaa” font_container=”tag:h1|font_size:35px|text_align:left|color:%23514c48|line_height:35px” use_theme_fonts=”yes”][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”3%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]Kirjoittanut:[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_custom_heading text=”Johanna Kalmari” font_container=”tag:h3|font_size:24px|text_align:left|color:%23514c48|line_height:24px” use_theme_fonts=”yes”][vc_custom_heading text=”Uute Scientific Oy” font_container=”tag:h4|font_size:16x|text_align:left|color:%23aaa5a2|line_height:16px” use_theme_fonts=”yes”][vc_custom_heading text=”Haartmaninkatu 4, 00014 Helsinki, FINLAND” font_container=”tag:h4|font_size:16x|text_align:left|color:%23aaa5a2|line_height:16px” use_theme_fonts=”yes”][vc_column_text]FM Johanna Kalmari on valmistunut It\u00e4<\/span>–<\/span>Suomen yliopistosta p\u00e4\u00e4aineenaan molekyylibiologia ja geeniteknologia.<\/span> Johanna<\/span>
ty\u00f6skenteli aiemmin ymp\u00e4rist\u00f6biotekniikan alalla<\/span> ja<\/span> t\u00e4ll\u00e4<\/span> hetkell\u00e4<\/span> h\u00e4n on<\/span> Uute Scientific Oy:n projektip\u00e4\u00e4llikk\u00f6<\/span> sek\u00e4 tohtoriopiskelija<\/span>
Ta<\/span>mpereen Yliopistossa, L\u00e4\u00e4ketieteen ja Terveysteknologian tiedekunnassa<\/span><\/span>.[\/vc_column_text][divider line_type=”No Line” custom_height=”50px”][vc_custom_heading text=”IIDA M\u00c4KEL\u00c4” font_container=”tag:h3|font_size:24px|text_align:left|color:%23514c48|line_height:24px” use_theme_fonts=”yes”][vc_custom_heading text=”Uute Scientific Oy” font_container=”tag:h4|font_size:16x|text_align:left|color:%23aaa5a2|line_height:16px” use_theme_fonts=”yes”][vc_custom_heading text=”Haartmaninkatu 4, 00014 Helsinki, FINLAND” font_container=”tag:h4|font_size:16x|text_align:left|color:%23aaa5a2|line_height:16px” use_theme_fonts=”yes”][vc_column_text]<\/span>FM Iida M\u00e4kel\u00e4 on v<\/span>almistunut Helsingin Yliopiston<\/span> Ymp\u00e4rist\u00f6n muutos<\/span> ja globaali kest\u00e4vyys maisteriohjelmasta vuonna 2021. Iida<\/span>
on<\/span> aiemmin<\/span> ty\u00f6skennelly<\/span>t<\/span> ADELE<\/span>–<\/span>tutkimushankkeessa,<\/span> jonka<\/span> tavoitteena<\/span> on<\/span> tutkia<\/span> ja<\/span> l\u00f6yt\u00e4\u00e4<\/span> luontopohjaisia<\/span> ratkaisuja<\/span>
immuunij\u00e4rjestelm\u00e4n h\u00e4iri\u00f6iden kasvavaan m\u00e4\u00e4r\u00e4\u00e4n erityisesti kaupungeissa. H\u00e4n t<\/span>y\u00f6skentelee tuotep\u00e4\u00e4llikk\u00f6n\u00e4 Uute Scientific<\/span>
Oy:ss\u00e4, sek\u00e4 tekee v\u00e4it\u00f6skirjaansa Helsingin Yliopiston ymp\u00e4rist\u00f6alan tieteidenv\u00e4lisess\u00e4 tohtoriohjelmassa<\/span><\/span>.[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”2%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”extra-color-2″][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”4%” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text css=”.vc_custom_1676995154097{padding-bottom: 2% !important;}”]\n
Immuunij\u00e4rjestelm\u00e4mme Tarvitsee Mikrobialtistusta<\/strong><\/h5>\n[\/vc_column_text][vc_column_text css=”.vc_custom_1690959929527{padding-bottom: 2% !important;}”]\n
Re-connecting Nature\u2122 -uutteen Tuoma Monimuotoinen Mikrobialtistus Tukee Immuunij\u00e4rjestelm\u00e4n Toimintaa<\/strong><\/h5>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_column_text]AVAINSANAT: Biodiversiteetti, Kaupungistuminen, Immuuniv\u00e4litteiset sairaudet, Ymp\u00e4rist\u00f6, Mikrobiomi, Sytokiini, Hy\u00f6<\/span>dyt<\/span> iholle<\/span><\/span><\/p>\n

TIIVISTELM\u00c4: Biologisen monimuotoisuuden v\u00e4heneminen, kau<\/span>pungistuminen ja immuuniv\u00e4litteiset sairaudet ovat lis\u00e4\u00e4ntyneet<\/span>
samanaikaisesti. Immuunij\u00e4rjestelm\u00e4 tarvitsee jatkuvaa stimulaatiota ymp\u00e4rist\u00f6st\u00e4 toimiakseen kunnolla ja erottaakseen haital<\/span>liset<\/span>
kohteet harmittomista. Yksinkertaisesti sanottuna: tuhoa pato<\/span>geeniset<\/span> mikrobit<\/span>, \u00e4l\u00e4 omia solujasi. Altistuminen ymp\u00e4rist\u00f6n mikro<\/span>–<\/span>
organismeille tuo monimuotoisuutta iholle ja suolistoon ja auttaa immuunij\u00e4rjestelm\u00e4\u00e4mme hiljent\u00e4m\u00e4\u00e4n tulehdukseen johtavia<\/span>
signaaleja. Re<\/span>–<\/span>Connecting Nature\u00ae on mikrobiuute Suomen luonnost<\/span>a ja se on suunniteltu lis\u00e4tt\u00e4v\u00e4ksi kuluttajatuotteisiin. Se takaa<\/span>
runsaan m\u00e4\u00e4r\u00e4n turvallista mikrobialtistusta erityisesti niille ihmisille, jotka eiv\u00e4t ole p\u00e4ivitt\u00e4in kosketuksissa luontoon.<\/span> In vitro<\/span>
tutkimuksen mukaan<\/span> Re<\/span>–<\/span>Connecting Nature\u00ae k\u00e4sittely v\u00e4h<\/span>ent\u00e4\u00e4 tulehdusta edist\u00e4vien sytokiinien muodostumista ihomallissa<\/span> ja<\/span>
viimeisin in vivo tutkimus tukee saatuja in vitro havaintoja. Ihon suojakerroksen toiminta vahvistui Re<\/span>–<\/span>Connecting Nature\u00ae<\/span> –<\/span>uut<\/span>etta<\/span>
sis\u00e4lt\u00e4neen voiteen k\u00e4yt\u00f6ll\u00e4 jo kolmessa viikossa<\/span>.<\/span> Tulos<\/span> on linjassa aiempien yliopistotutkimusten kanssa, joissa lis\u00e4tty kontakti<\/span>
luontoon vaikutti my\u00f6nteisesti p\u00e4iv\u00e4kotilasten immuunipuolustusta s\u00e4\u00e4televien sytokiinien tasoon.<\/span><\/span>
\n<\/span>[\/vc_column_text][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][image_with_animation image_url=”1969″ image_size=”full” animation_type=”entrance” animation=”Fade In” hover_animation=”none” alignment=”” border_radius=”15px” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”4%” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text css=”.vc_custom_1676995167148{padding-bottom: 2% !important;}”]\n

Biologinen Monimuotoisuus Kasvattaa Immuunij\u00e4rjestelm\u00e4n S\u00e4\u00e4telykyky\u00e4<\/strong><\/h5>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_column_text]Urbaani, rakennettu ymp\u00e4rist\u00f6 ja muutokset el\u00e4m\u00e4ntavoissa ovat<\/span> v\u00e4hent\u00e4neet ihmisten kosketusta luontoon ja sen biologiseen<\/span>
monimuotoisuuteen.<\/span> Maailman<\/span> allergiaj\u00e4rjest\u00f6<\/span> on<\/span> huolissaan<\/span> kaupungistumisen<\/span> tuomasta<\/span> ymp\u00e4rist\u00f6n<\/span> monimuotoisuuden<\/span>
k\u00f6yhtymisest\u00e4<\/span>. Makro<\/span>tason monimuotoisuuden (<\/span>esim.<\/span> kasvit) v\u00e4hentyminen kaupungeissa tuo mukanaan mikrotason k\u00f6yhtymisen<\/span>
(mikrobit)<\/span>, jolloin ihmisen saama mikrobialtistus on pienempi.<\/span> T\u00e4m\u00e4 heikent\u00e4\u00e4 immuunij\u00e4rjestelm\u00e4n s\u00e4\u00e4telykyky\u00e4<\/span> ja johtaa lopulta<\/span>
tulehdustilaan ja sairauksi<\/span>in (1). Suomen kansallinen allergiaohjelma vuosina<\/span> 2008<\/span>\u2013<\/span>2018<\/span> muutti asenteita allergeenien v\u00e4ltt\u00e4misest\u00e4<\/span>
niille sied\u00e4tt\u00e4miseen ja onnistui<\/span> v\u00e4hent\u00e4m\u00e4\u00e4n allergioiden ja astman esiintyvyytt\u00e4 (2).<\/span><\/span><\/span><\/p>\n


Biodiversiteettihypoteesin mukaan<\/span> kosketus luontoymp\u00e4rist\u00f6\u00f6n ri<\/span>kastuttaa ihmisen mikrobiomia, edist\u00e4\u00e4 immuunij\u00e4rjestelm\u00e4n<\/span>
tasapainoa ja suojaa allergioilta<\/span> sek\u00e4<\/span> tulehduksellisilta h\u00e4iri\u00f6tiloilta (7).<\/span> Ihmiset ovat kehittyneet el\u00e4m\u00e4\u00e4n yhdess\u00e4 mikro<\/span>–<\/span>organismien <\/span><\/span>kanssa<\/span>,<\/span> ja<\/span> siksi<\/span> jokap\u00e4iv\u00e4inen<\/span> kontakti<\/span> ymp\u00e4rist\u00f6n<\/span> mikrobeih<\/span>in<\/span> yll\u00e4pit\u00e4\u00e4<\/span> immuunij\u00e4rjestelm\u00e4\u00e4<\/span> s\u00e4\u00e4televi\u00e4<\/span> toimintoja,<\/span> jotka<\/span>
tasapainottavat reaktioita vieraisiin proteiineihin, kuten allergeeneihin. Immuunij\u00e4rjestelm\u00e4ll\u00e4 on vaikeuksia erottaa vaaral<\/span>liset<\/span>
signaalit vaarattomista, jos vuoropuhelu ymp\u00e4rist\u00f6n mikrobien k<\/span>anssa puuttuu.<\/span> T\u00e4ll\u00f6in<\/span> voi k\u00e4yd\u00e4 niin, ett\u00e4 immuunij\u00e4rjestelm\u00e4<\/span>
tunnistaa siitep\u00f6lyn virukseksi (4).<\/span> V\u00e4hentynyt<\/span> biodiversiteettialtistus<\/span> ja<\/span> muutokset suolen ja ihon mikrobiomissa ovat yhteydess\u00e4<\/span>
moniin h\u00e4iri\u00f6ihin<\/span>, jotka liittyv\u00e4t<\/span> kohonneeseen tulehdusvasteeseen,<\/span> kuten<\/span> astmaan, allergiaan, tulehdukselliseen suolistosairauteen,<\/span>
tyypin 1 diabetekseen ja liikalihavuuteen (1,5).<\/span><\/span><\/span><\/p>\n


Ihon, suolen ja hengitysteiden kautta tapahtuva altistuminen y<\/span>mp\u00e4rist\u00f6n mikrobeille<\/span> saa molekyylitasolla aik<\/span>aan positiivisia,<\/span>
immuunij\u00e4rjestelm\u00e4\u00e4<\/span> s\u00e4\u00e4televi\u00e4<\/span> tapahtumaketjuja<\/span> ja<\/span> samaan<\/span> aikaan<\/span> ep\u00e4<\/span>edulliset<\/span> tulehdukselliset<\/span> vasteet<\/span> vaimentuvat<\/span> (5).<\/span>
Ymp\u00e4rist\u00f6mikrobien jatkuvasti stimuloima immuunij\u00e4rjestelm\u00e4<\/span> tuottaa<\/span> j\u00e4rjestelm\u00e4\u00e4<\/span> s\u00e4\u00e4televi\u00e4 T<\/span>–<\/span>soluja (Treg), joita tar<\/span>vitaan<\/span>
vaimentamaan tulehdusvasteita. Stimuloinnin puuttuessa Treg solujen m\u00e4\u00e4r\u00e4 v\u00e4henee (3,6).<\/span> My\u00f6s epiteelisolut tarvitsevat<\/span>
mikrobivuorovaikutusta<\/span> eheyden, sietokyvyn ja kudosten korjaustoimintojen kehittymiselle ja yll\u00e4pit\u00e4miselle.<\/span> Ilman riitt\u00e4v\u00e4\u00e4<\/span>
mikr<\/span>obistimulaatiota<\/span> aktivoituu<\/span> toinen polku, itse\u00e4\u00e4n yll\u00e4pit\u00e4v\u00e4 j\u00e4rjestelm\u00e4, jossa on lis\u00e4\u00e4ntynyt m\u00e4\u00e4r\u00e4 tulehdusv\u00e4litt\u00e4ji\u00e4 ja n\u00e4it\u00e4<\/span>
siet\u00e4vi\u00e4 mikrobeja.<\/span> Ymp\u00e4rist\u00f6 muokkaa immuunij\u00e4rjestelm\u00e4\u00e4mme my\u00f6s epigeneettisill\u00e4 mekanismeilla, joissa ymp\u00e4rist\u00f6tekij\u00e4t<\/span>
aktivoivat ja hiljent\u00e4v\u00e4t geenej<\/span>\u00e4. T\u00e4m\u00e4 epigeneettinen modulaatio on erityisen t\u00e4rke\u00e4\u00e4 varhaislapsuudessa, mutta muutoksia voi<\/span>
tapahtua my\u00f6s my\u00f6hemmin (5).<\/span><\/span><\/span><\/p>\n


Ihon ja suolen pinnalla el\u00e4v\u00e4 mikrobiomi on t\u00e4rke\u00e4 immuunij\u00e4rjestelm\u00e4lle ja terveydelle. Tilanne, jossa jo<\/span>nkin<\/span> laji<\/span>n m\u00e4\u00e4r\u00e4<\/span> kasvaa<\/span>
y<\/span>lett\u00f6m\u00e4sti<\/span> tois<\/span>t<\/span>en m\u00e4\u00e4r\u00e4n v\u00e4hetess\u00e4 (<\/span>=<\/span>dysbio<\/span>osi<\/span>)<\/span>,<\/span> yhdistet\u00e4\u00e4n sairauksiin kuten atooppiseen ihottumaan (14). Ihon ja suolen<\/span>
mikrobiomi<\/span> koostuu<\/span> sek\u00e4<\/span> v\u00e4liaikaisista<\/span> ett\u00e4<\/span> pysyvist\u00e4<\/span> mikrobeista<\/span> ja<\/span> on<\/span> siten<\/span> ainakin<\/span> osittain<\/span> jatkuvassa,<\/span> muuttuvassa<\/span>
vuorovaikutuk<\/span>sessa ymp\u00e4rist\u00f6n kanssa<\/span> (1). Ymp\u00e4rist\u00f6 muuttaa siten mikrobiomiamme, ja on osoitettu, ett\u00e4 atooppista ihottumaa<\/span>
sairastavien asuinymp\u00e4rist\u00f6ss\u00e4 on alhaisempi biologinen monimuotoisuus ja<\/span> pienempi<\/span> g<\/span>ammaproteobakteer<\/span>ien monimuotoisuus<\/span>
iholla<\/span> kuin terveill\u00e4 yk<\/span>sil\u00f6ill\u00e4<\/span> (27). Jotkut ymp\u00e4rist\u00f6<\/span>st\u00e4<\/span> per\u00e4is<\/span>in olevat<\/span> mikrobit ovat erityisen<\/span> hy\u00f6dyllisi\u00e4<\/span> terveydelle ja<\/span> niill\u00e4 on<\/span>
tulehdusta<\/span> ehk\u00e4isevi\u00e4<\/span> ominaisuuksia.<\/span> Esimerkiksi<\/span> gammaproteobakteerit<\/span> ja<\/span> siihen<\/span> kuuluva<\/span> Acinetobacter<\/span>–<\/span>suku<\/span> tehostaa<\/span>
immuunis\u00e4\u00e4tely\u00e4 (8, 14) ja ehk\u00e4isee allergista herkistymist\u00e4 ja keuhkojen tulehdusta (10).<\/span> Pohjoisista mets\u00e4npohjista l\u00f6ytyv\u00e4ll\u00e4<\/span>
Mycobacterium<\/span> suvun bakteereilla on tulehdusta ehk\u00e4isevi\u00e4 ominaisuuksia ja ne on yhdistetty<\/span> mielialaa ja oppimista parantavaan<\/span>
vaikutukseen sek\u00e4 stressin ja masennuksen lieventymiseen (9, 14).<\/span><\/span><\/span><\/p>\n


Positiivisia<\/span> tuloksia<\/span> on<\/span> saatu<\/span> i<\/span>nterventiokokeista<\/span>,<\/span> joissa<\/span> on<\/span> palautettu<\/span> kosketus<\/span> mikrobiologisesti<\/span> monimuotois<\/span>ii<\/span>n<\/span>
luonnonmateriaaleihin<\/span> ja<\/span> siten<\/span> saatu<\/span> aikaan<\/span> hy\u00f6dyllisi\u00e4<\/span> immunologisia<\/span> muutoksia<\/span> (<\/span>11<\/span>\u2013<\/span>14<\/span>).<\/span> Er\u00e4\u00e4ss\u00e4<\/span> p<\/span>\u00e4iv\u00e4kotitutkimuksessa<\/span>
mets\u00e4pohjainen piha<\/span> monipuolisti<\/span> lasten<\/span> ihon ja suolen mikrobiomia, lis\u00e4si<\/span> immuunij\u00e4rjestelm\u00e4\u00e4 s\u00e4\u00e4televien<\/span> Treg solujen m\u00e4\u00e4r\u00e4\u00e4 ja<\/span>
muutti<\/span> sytokiini<\/span>suhdetta edullisempaan suuntaan j<\/span>o 28 p\u00e4iv\u00e4n aikana. Toisessa<\/span>,<\/span> pidempikestoisessa<\/span> p\u00e4iv\u00e4koti<\/span>tutkimuksessa<\/span>
biologisesti<\/span> monimuotoinen<\/span> mets\u00e4pohjakasvillisuus<\/span> ja<\/span> turve<\/span> monipuolisti<\/span> lasten<\/span> ihon<\/span> kommensaalimikrobistoa<\/span> ja<\/span> v\u00e4hensi<\/span>
mahdollisten<\/span> patogeenien m\u00e4\u00e4r\u00e4\u00e4<\/span> verrattuna tavanomaiseen kaupunkimaiseen p\u00e4iv\u00e4kotiymp\u00e4rist\u00f6\u00f6n (14).<\/span><\/span><\/span><\/p>\n


Mikrobien tunnistus tapahtuu reseptoreissa (Pattern Recognition Receptors, PRR), joita l\u00f6ytyy erityyppisist\u00e4 soluista, kuten<\/span> ihon<\/span>
keratinosyyteist\u00e4. Reseptorit tunnistavat mikrobien<\/span> molek<\/span>yyli<\/span>rakenteita, kuten lipoproteiineja (29, 30)<\/span>,<\/span> ja t\u00e4st\u00e4 syyst\u00e4<\/span> rakenteet<\/span>
tunnist<\/span>etaan<\/span> ja immuunivaste syntyy, vaikka mikrobit olisivat inaktivoituja (10, 28). Re<\/span>–<\/span>Connecting Nature\u00ae<\/sup><\/span> –<\/span>uute on patentoitu,<\/span>
uraauurtava mikrobiologinen<\/span> valmiste<\/span>, joka on kehitet<\/span>ty Tampereen ja Helsingin yliopistoissa. Se sis\u00e4lt\u00e4\u00e4 v\u00e4hint\u00e4\u00e4n 600 erilaista<\/span>
bakteerilajia (mukaan lukien hy\u00f6dylliset<\/span> Acinetobacter<\/span> ja<\/span> Mycobacterium<\/span> suvut) turvallisessa muodossa: inaktivoituina, mutta<\/span>
biokemiallisesti tunnistettavina antamaan immuunij\u00e4rje<\/span>stelm\u00e4lle sen tarvitsemaa luontoaltistusta. Re<\/span>–<\/span>Connecting Nature\u00ae<\/span> –<\/span>uutetta<\/span>
on t\u00e4ll\u00e4 hetkell\u00e4 saatavilla<\/span> useiden eri valmistajien<\/span> kosmetiikkatuotteissa<\/span>,<\/span> ja my\u00f6s Ruskovilla on tehnyt oman Mets\u00e4<\/span> –<\/span>malliston<\/span>, jossa<\/span>
tekstiileihin on lis\u00e4tty Re<\/span>–<\/span>Connecting Nature\u00ae<\/span> –<\/span>uutetta<\/span><\/span>.[\/vc_column_text][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”2%” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][image_with_animation image_url=”2998″ image_size=”full” animation_type=”entrance” animation=”Fade In” hover_animation=”none” alignment=”” border_radius=”15px” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][vc_column_text]Kuva 1<\/span>.<\/span><\/strong> Ihon l\u00e4pi tapahtuva veden haihtuminen (transepidermal water loss, TEWL<\/span> g\/m<\/span>2<\/span>h)<\/span> en<\/span>nen<\/span> kem<\/span>ikaali\u00e4rsytyst\u00e4<\/span> (SLS irritation)<\/span> ja<\/span>
sen j\u00e4lkeen<\/span>.<\/span> Te<\/span>stialueilla oli k\u00e4ytetty voiteita, joko<\/span> Re<\/span>–<\/span>Connecting Nature\u00ae (RCN)<\/span> –<\/span>uutetta sis\u00e4lt\u00e4v\u00e4<\/span>\u00e4 tai lumevoidetta<\/span> (<\/span>Placebo),<\/span> kolme<\/span>
viikkoa ennen \u00e4rsytyst\u00e4<\/span> sek\u00e4 \u00e4rsytyksen j\u00e4lkeen<\/span>.<\/span> L<\/span>umevoiteella k\u00e4sitelty<\/span> iho<\/span> reagoi<\/span> voimakkaammin<\/span> kemikaali\u00e4rsytyks<\/span>een kuin<\/span> Re<\/span>–<\/span>
Connecting Nature<\/span>\u00ae<\/span> –<\/span>uutetta sis\u00e4lt\u00e4v\u00e4ll\u00e4 voiteella k\u00e4sitelty<\/span> ihoalue<\/span>.<\/span> Ero<\/span> oli tilastollisesti merkitsev\u00e4<\/span> (N=6; P<\/span>–<\/span>value <0.05<\/span>,<\/span> parittai<\/span>nen<\/span>
t<\/span>–<\/span>testi keskiarvoille<\/span>)<\/span>.<\/span><\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”4%” bottom_padding=”2%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text css=”.vc_custom_1676995418115{padding-bottom: 2% !important;}”]\n

Re-connecting nature\u00ae<\/sup> -uutteen tuomat hy\u00f6dyt iholle<\/strong><\/h5>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_column_text]Perustuen kirjallisuuteen ja t\u00e4ss\u00e4 esitettyihin in vitro sek\u00e4 in vivo koetuloksiin, Re-Connecting Nature\u00ae -uutetta sis\u00e4lt\u00e4vien tuotteiden
\nk\u00e4yt\u00f6ll\u00e4 on useita hy\u00f6tyj\u00e4 iholle. Re-Connecting Nature\u00ae -uute suositetulla pitoisuudella tukee ihon luonnollisen mikrobiomin
\nmonimuotoisuutta ja voi est\u00e4\u00e4 patogeenien, kuten S. aureus bakteerin liiallista kasvua. Re-Connecting Nature\u00ae -uute voi tukea my\u00f6s
\nihon suojakerroksen toimintaa alentamalla tulehdusta edist\u00e4vien (erityisesti IL-4, IL-13, TNF\u03b1 and IFN\u03b3) sytokiinien m\u00e4\u00e4r\u00e4\u00e4, jotka on
\nyhdistetty ihon suojakerroksen toiminnan h\u00e4iri\u00f6ihin useissa tutkimuksissa (15-21). Atooppiseen ihottumaan liitet\u00e4\u00e4n tyypillisesti ihon
\nsuojakerroksen toiminnan h\u00e4iri\u00f6, S. aureus patogeenin ylikasvu ja kohonneet IL-4 ja IL-13 sytokiinien tasot (18, 31). Lis\u00e4ksi siihen
\nliittyy kutina, joka on ainakin osittain IL-4 sytokiinin v\u00e4litt\u00e4m\u00e4\u00e4 (22). Tarvitaan lis\u00e4\u00e4 tutkimuksia, mutta perustuen kirjallisuuteen ja
\nsaatuihin in vitro ja in vivo koetuloksiin vaikuttaa silt\u00e4, ett\u00e4 Re-Connecting Nature\u00ae -uutteella on vahva potentiaali atooppisen
\nihottuman oireiden lievitt\u00e4miseen sek\u00e4 normaali ihon suojakerroksen vahvistamiseen.<\/p>\n

Ihon suojakerroksen h\u00e4iri\u00f6t\u00e4 voi esiinty\u00e4 my\u00f6s ilman kliinist\u00e4 sairautta. Suojakerroksen toiminta alkaa heikenty\u00e4 ja korjaantuminen
\nhidastua 55 ik\u00e4vuoden j\u00e4lkeen. Ik\u00e4\u00e4ntyv\u00e4ss\u00e4 ihossa on todettu matala-asteista tulehdusta (23). My\u00f6s psykologinen stressi h\u00e4iritsee
\nihon suojakerroksen toimintaa, joka voi liitty\u00e4 stressin aikaansaamaan lis\u00e4\u00e4ntyneeseen tulehdusta edist\u00e4vien sytokiinien
\nmuodostumiseen (16). Jotkut sytokiinit, kuten TNF\u03b1 and IFNg, inhiboivat my\u00f6s kollageenin muodostumista (24, 25). N\u00e4in ollen
\ntulehdusta edist\u00e4vien sytokiinien m\u00e4\u00e4r\u00e4n alentaminen auttaa s\u00e4ilytt\u00e4m\u00e4\u00e4n ihon suojakerroksen normaalin toiminnan ja kollageenin
\nmuodostumisen ik\u00e4\u00e4ntyv\u00e4ss\u00e4 ihossa ja stressaavissa el\u00e4m\u00e4ntilanteissa. Sytokiinien kuten IFNg m\u00e4\u00e4r\u00e4n alentaminen voi my\u00f6s
\nnopeuttaa ihon uusiutumista ja korjaantumista (25). Liiallisen UV-s\u00e4teilyn aikaansaamat oireet auringon polttamassa ihossa
\naiheutuvat tulehduksellisista reaktioista, kuten TNF\u03b1 ja IL-1b muodostumisesta (26). Alentamalla tulehdusta edist\u00e4vien sytokiinien
\nm\u00e4\u00e4r\u00e4\u00e4 voidaan helpottaa my\u00f6s auringonpolttamaan ihoon liittyv\u00e4\u00e4 punoitusta ja \u00e4rsytyst\u00e4.<\/p>\n

 <\/p>\n

Kirjallisuuskatsaus yhdist\u00e4\u00e4 alentuneet tulehdusta edist\u00e4vien sytokiinien tasot ihohy\u00f6tyihin. Tiedon yhdist\u00e4minen saatuihin<\/span> in<\/span> vitro<\/span>
tuloksiin ava<\/span>a lupaavia mahdollisuuksia<\/span> Re<\/span>–<\/span>Connecting Nature\u00ae<\/span> –<\/span>uutteen k\u00e4yt\u00f6lle eri tuotteissa.<\/span> Tehty<\/span> in vivo<\/span> tutkimus tuki edelleen<\/span>
in vitro<\/span> ihomallissa saatuja sytokiinituloksia.<\/span> Re<\/span>–<\/span>Connecting Nature\u00ae<\/span> –<\/span>uutteen<\/span> s\u00e4\u00e4nn\u00f6llisen k\u00e4yt\u00f6n hy\u00f6dyt<\/span> n\u00e4kyiv\u00e4t jo kolmessa<\/span>
viikossa<\/span> ihon korkeampana stressinsietokykyn\u00e4 kemiallista \u00e4rsytyst\u00e4 vastaan.<\/span> Ihonhoidollisten hy\u00f6tyjen lis\u00e4ksi pitk\u00e4n aikav\u00e4lin<\/span>
tavoittee<\/span>mme on kehitt\u00e4\u00e4 keinoja<\/span> immuuniv\u00e4litteisten sairauksien ehk\u00e4isyyn.<\/span><\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” top_padding=”5%” bottom_padding=”5%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”Full Width Line” line_thickness=”1″ divider_color=”extra-color-2″ custom_height=”1″][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” top_padding=”5%” bottom_padding=”2%” top_padding_phone=”10%” bottom_padding_phone=”4%” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]\n

L\u00e4hteet<\/h5>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_column_text]\n
    \n
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  2. Haahtela, T., Von Hertzen, L., M\u00e4kel\u00e4, M., H<\/span>annuksela, M., Klaukka, T., Korhonen, K., … & Vidgren, P. (2008). Kansallinen allergiaohjelma 2008<\/span>\u2013<\/span>2018<\/span>\u2013<\/span>aika muuttaa suuntaa.<\/span> Suomen l\u00e4\u00e4k\u00e4rilehti<\/span>,<\/span> 14<\/span>(2008), 9<\/span>–<\/span>22.<\/span><\/span><\/span><\/span><\/li>\n
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  9. F<\/span>rank, M. G., Fonken, L. K., Dolzani, S. D., Annis, J. L., Siebler, P. H., Schmidt, D., …<\/span><\/span> & Lowry, C. A. (2018). Immunization with Mycobacterium <\/span>vaccae<\/span> induces an anti<\/span>–<\/span>inflammatory milieu in the CNS: attenuation of stress<\/span>–<\/span>induced microglial priming, alarmins and anxiety<\/span>–<\/span>like <\/span>behavior.<\/span><\/span> Brain, behavior, and immunity<\/span>,<\/span> 73<\/span>, 352<\/span>–<\/span>363.<\/span><\/span><\/span><\/span><\/li>\n
  10. Fyhrquist, N., Ruokolainen, L., Suomalainen, A., Lehtim\u00e4ki, S., Veckman, V.,<\/span> Vendelin, J., …<\/span><\/span> & Alenius, H. (2014). Acinetobacter species in the skin <\/span>microbiota protect against allergic sensitization and inflammation.<\/span><\/span> Journal of Allergy and Clinical Immunology<\/span>,<\/span> 134<\/span>(6), 1301<\/span>–<\/span>1309.<\/span><\/span><\/span><\/span><\/li>\n
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  14. Roslund, M.<\/span> I., Puhakka, R., Nurminen, N., Oikarinen, S., Siter, N., Gr\u00f6nroos, M., …<\/span><\/span> & Vari, H. K. (2021). Long<\/span>–<\/span>term biodiversity intervention <\/span>shapes health<\/span>–<\/span>associated commensal microbiota among urban day<\/span>–<\/span>care children.<\/span><\/span> Environment International<\/span>,<\/span> 157<\/span>, 106811.<\/span><\/span><\/span><\/li>\n
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  17. Howell, M. D., Kim, B. E., Gao, P., Grant, A. V.,<\/span> Boguniewicz<\/span>, M.,<\/span> DeBenedetto<\/span>, A., … & Leung, D. Y. (2009). Cytokine modulation of atopic <\/span>dermatitis filaggrin skin<\/span> expression.<\/span> Journal of Allergy and Clinical Immunology<\/span>,<\/span> 124<\/span>(3), R7<\/span>–<\/span>R12.<\/span><\/span><\/li>\n
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    <\/span><\/span><\/li>\n
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