Tackling the global auto-immune health crisis

The United Nations has predicted that By 2050, two-thirds of the global human population will live in urban areas with little green space and limited contact with nature and biodiversity.

Scientists have also established clear links between global health pandemics and the loss of biodiversity.

It is time for us to reconnect with nature.

The growth of immune mediated diseases

Scientists began noticing a steep increase in autoimmune disease and allergies cases in the 1980’s. It is thought that the industrial revolution was a significant contributor to this rise.

Over 50% of global population now live inside city borders and increasingly in highly urbanised megacities. Although COVID-19 pandemic has created some movement back to less densely populated and rural areas, the megatrend of urbanisation continues on a global scale.

City-life can bring many benefits for its inhabitants, but the lack of natural environments and especially lack of physical touch with biodiversity-rich nature brings us new immune system-related problems that can create huge financial costs for societies as well as humane burden for the individuals and their families who are suffering from immune-mediated diseases.

Recent estimates state that as much as 4.5 per cent of the world’s population suffers from an autoimmune disease.

That’s over 350 million people.

“In the UK alone, at least 4 million people have developed auto immune diseases with some individuals suffering more than one. Internationally, it is now estimated that cases of autoimmune diseases are rising by between 3% and 9% a year. Most scientists believe environmental factors play a key role in this rise.”

The Guardian

Urban dwellers are seeing the biggest impact

Urbanisation and increased sanitisation are two of the most significant factors threatening natural biodiversity. City dwellers have a much higher incidence of autoimmune diseases due to the decrease in contact with natural environments.

This is particularly important for children as research has shown that the more microbial agents that children are exposed to early in life, the less likely they are to develop allergies and autoimmune diseases.

Scientific research and evidence

Scientific research and evidence into the benefits of exposure to microbial diversity for children

The ADELE research group carried out the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children.

Changes in the skin and gut microbiota and blood immune markers of children were analysed over a 28-day period. Their findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies.

View publication on science.org
“Exposure for as little as two weeks can improve the biodiversity of a human living in a city.”

Heikki Hyöty, MD, PhD

Professor of Virology at Tampere University, Co-Founder of Uute Scientific Oy

Aki explaining the research (3 mins)

ADELE Research Group Leader Aki Sinkkonen explaining the on-going PREVALL research and kindergarten results (3 min)

The ‘Hygiene hypothesis’ and Karelia

Recent results from a study in Russian Karelia and Finland imply that environmental factors have contributed to the increasing prevalence of immune-mediated disorders.

In this study, it was observed that the incidence of diabetes 1 in 0-14-year-old children is six times lower in Russian Karelia than that in Finland. And, a range of additional immune-mediated diseases of those children was shown to be much more common in Finland than in Russian Karelia.

Key scientific studies and reports


Our research shows that Re-Connecting Nature® stimulates the immune system

Our in-vitro studies show that Re-Connecting Nature® extract reduces the amount of pro-inflammatory cytokines released in an epidermis skin model. These results are supported by previous university studies in which re-introducing natural microbial diversity to the skin of daycare children improved their blood cytokine ratio for attenuated inflammatory signalling.

Re-Connecting Nature is scientifically proven

to stimulate the immune system

Developed at the Universities of Tampere and Helsinki, our pioneering microbial extract replicates the microbial diversity of Finnish nature and restores your immune system's natural balance.

Bringing you the microbial diversity of Finnish nature

Finnish soil's microbial diversity can promote health and well-being, and so we have created a ‘world-first’ ingredient which is safe and easy to use.

Scientifically proven to stimulate the immune system

A recent study by Uute Scientific showed a statistically significant reduction in the levels of seven pro-inflammatory cytokines.


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